Publications

Pre-ETH Zürich (Doctoral work)

2020

Fungal-derived brevianamide assembly by a stereoselective semipinacolase

Ying Ye, Lei Du, Xingwang Zhang, Sean A. Newmister, Morgan McCauley, Juan V. Alegre-Requena, Wei Zhang, Shuai Mu, Atsushi Minami, Amy E. Fraley, Maria L. Androver-Castellano, Nolan A. Carney, Vikram V. Shende, Feifei Qi, Hideaki Oikawa, Hikaru Kato; Sachiko Tsukamoto, Robert S. Paton, Robert M. Williams, David H. Sherman, Shengying Li.
Nature Catalysis, vol. 3, pp. 497-506, Springer Nature, 2020.
external pageDOI:10.1038/s41929-020-0454-9

Flavin-dependent monooxygenases NotI and NotI' mediate spiro-oxindole formation in biosynthesis of the notoamides

Amy E. Fraley, Hong T. Tran, Samantha P. Kelly, Sean A. Newmister, Ashootosh Tripathi, Hikaru Kato, Sachiko Tsukamoto, Lei Du, Shengying Li, Robert M. Williams, David H. Sherman.
ChemBioChem., vol. 21, pp. 2449-2454. Weinheim: Wiley-VCH, 2020.
external pageDOI: 10.1002/cbic.202000004

Enzyme evolution in fungal indole alkaloid biosynthesis

Amy E. Fraley, David H. Sherman
FEBS Journal. vol. 287, pp. 1381-1402, FEBS Press, 2020.
external pageDOI:10.1111/febs.15270

Molecular basis for spirocycle formation in the paraherquamide biosynthetic pathway

Amy E. Fraley, Kersti Caddell Haatveit, Ying Ye, Samantha P. Kelly, Fengan Yu, Robert M. Williams, Janet L. Smith, K. N. Houk, David H. Sherman.
Journal of the American Chemical Society, vol. 142, issue 5, pp. 2244-2251, ACS Publications, 2020
external pageDOI: 10.1021/jacs.9b09070

2019

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase

Qingyun Dan, Sean A. Newmister, Kimberly R. Klas, Amy E. Fraley, Timothy J. McAfoos, Amber D. Somoza, James D. Sunderhaus, Ying Ye, Vikram V. Shende, Fengan Yu, W. Clay Brown, Le Zhao, Janet L. Smith, Robert M. Williams, David H. Sherman.
Nature Chemistry, vol. 11, pp. 972-980, Springer Nature, 2019.
external pageDOI: 10.1038/s41557-019-0326-6

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

Tyler S. Beyett, Amy E. Fraley, Emily Labudde, Dhabaleswar Patra, Ryan C. Coleman, Akito Eguchi, Alisa Glukhova, Robert M. Williams, Janet L. Smith, David H. Sherman, John J. G. Tesmer.
Proceedings of the National Academy of Sciences of the USA, vol. 116, no. 32, pp. 15895-15900, National Academy of Sciences, 2019.
external pageDOI: 10.1073/pnas.181854711

2018

Halogenase engineering and its utility in medicinal chemistry

Amy E. Fraley, David H. Sherman.
Bioorganic and Medicinal Chemistry Letters, vol. 28, no. 11, pp. 1992-1999, Elsevier, 2018.
external pageDOI: 10.1016/j.bmcl.2018.04.066

Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi

Kimberly R. Klas, Hikaru Kato, Jens C. Frisvad, Fengan Yu, Sean A. Newmister, Amy E. Fraley, David H. Sherman, Sachiko Tsukamoto, Robert M. Williams.
Natural Product Reports, vol. 35, no. 6, pp. 532-558, Royal Society of Chemistry, 2018.
external pageDOI: 10.1039/C7NP00042A

PKS- NRPS enzymology and structural biology: considerations in protein production

Meredith A. Skiba, Finn P. Maloney, Qingyun Dan, Amy E. Fraley, Courtney C. Aldrich, Janet L. Smith, W. Clay Brown
Methods in Enzymology, vol. 604, pp. 45-88, Elsevier, 2018
external pageDOI: 10.1016/bs.mie.2018.01.035

2017

Function and structure of MalA/MalA', iterative halogenases for late-stage C–H functionalization of indole alkaloids

Amy E. Fraley, Marc Garcia-Borràs, M.; Ashootosh Tripathi, Dheeraj Khare, Eduardo V. Mercado-Marin, Hong Tran, Qingyun Dan, Gabrielle P. Webb, Katharine R. Watts, Phillip Crews, Richmond Sarpong, Robert M. Williams, Janet L. Smith, K. N. Houk, and David H. Sherman
Journal of the American Chemical Society, vol. 139, no. 34, pp. 12060-12068, ACS Publications, 2017
external pageDOI: 10.1021/jacs.7b06773