Publications
Pre-ETH Zürich (Doctoral work)
2020
Fungal-derived brevianamide assembly by a stereoselective semipinacolase
Ying Ye, Lei Du, Xingwang Zhang, Sean A. Newmister, Morgan McCauley, Juan V. Alegre-Requena, Wei Zhang, Shuai Mu, Atsushi Minami, Amy E. Fraley, Maria L. Androver-Castellano, Nolan A. Carney, Vikram V. Shende, Feifei Qi, Hideaki Oikawa, Hikaru Kato; Sachiko Tsukamoto, Robert S. Paton, Robert M. Williams, David H. Sherman, Shengying Li.
Nature Catalysis, vol. 3, pp. 497-506, Springer Nature, 2020.
external page DOI:10.1038/s41929-020-0454-9
Flavin-dependent monooxygenases NotI and NotI' mediate spiro-oxindole formation in biosynthesis of the notoamides
Amy E. Fraley, Hong T. Tran, Samantha P. Kelly, Sean A. Newmister, Ashootosh Tripathi, Hikaru Kato, Sachiko Tsukamoto, Lei Du, Shengying Li, Robert M. Williams, David H. Sherman.
ChemBioChem., vol. 21, pp. 2449-2454. Weinheim: Wiley-VCH, 2020.
external page DOI: 10.1002/cbic.202000004
Enzyme evolution in fungal indole alkaloid biosynthesis
Amy E. Fraley, David H. Sherman
FEBS Journal. vol. 287, pp. 1381-1402, FEBS Press, 2020.
external page DOI:10.1111/febs.15270
Molecular basis for spirocycle formation in the paraherquamide biosynthetic pathway
Amy E. Fraley, Kersti Caddell Haatveit, Ying Ye, Samantha P. Kelly, Fengan Yu, Robert M. Williams, Janet L. Smith, K. N. Houk, David H. Sherman.
Journal of the American Chemical Society, vol. 142, issue 5, pp. 2244-2251, ACS Publications, 2020
external page DOI: 10.1021/jacs.9b09070
2019
Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase
Qingyun Dan, Sean A. Newmister, Kimberly R. Klas, Amy E. Fraley, Timothy J. McAfoos, Amber D. Somoza, James D. Sunderhaus, Ying Ye, Vikram V. Shende, Fengan Yu, W. Clay Brown, Le Zhao, Janet L. Smith, Robert M. Williams, David H. Sherman.
Nature Chemistry, vol. 11, pp. 972-980, Springer Nature, 2019.
external page DOI: 10.1038/s41557-019-0326-6
Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe
Tyler S. Beyett, Amy E. Fraley, Emily Labudde, Dhabaleswar Patra, Ryan C. Coleman, Akito Eguchi, Alisa Glukhova, Robert M. Williams, Janet L. Smith, David H. Sherman, John J. G. Tesmer.
Proceedings of the National Academy of Sciences of the USA, vol. 116, no. 32, pp. 15895-15900, National Academy of Sciences, 2019.
external page DOI: 10.1073/pnas.181854711
2018
Halogenase engineering and its utility in medicinal chemistry
Amy E. Fraley, David H. Sherman.
Bioorganic and Medicinal Chemistry Letters, vol. 28, no. 11, pp. 1992-1999, Elsevier, 2018.
external page DOI: 10.1016/j.bmcl.2018.04.066
Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi
Kimberly R. Klas, Hikaru Kato, Jens C. Frisvad, Fengan Yu, Sean A. Newmister, Amy E. Fraley, David H. Sherman, Sachiko Tsukamoto, Robert M. Williams.
Natural Product Reports, vol. 35, no. 6, pp. 532-558, Royal Society of Chemistry, 2018.
external page DOI: 10.1039/C7NP00042A
PKS- NRPS enzymology and structural biology: considerations in protein production
Meredith A. Skiba, Finn P. Maloney, Qingyun Dan, Amy E. Fraley, Courtney C. Aldrich, Janet L. Smith, W. Clay Brown
Methods in Enzymology, vol. 604, pp. 45-88, Elsevier, 2018
external page DOI: 10.1016/bs.mie.2018.01.035
2017
Function and structure of MalA/MalA', iterative halogenases for late-stage C–H functionalization of indole alkaloids
Amy E. Fraley, Marc Garcia-Borràs, M.; Ashootosh Tripathi, Dheeraj Khare, Eduardo V. Mercado-Marin, Hong Tran, Qingyun Dan, Gabrielle P. Webb, Katharine R. Watts, Phillip Crews, Richmond Sarpong, Robert M. Williams, Janet L. Smith, K. N. Houk, and David H. Sherman
Journal of the American Chemical Society, vol. 139, no. 34, pp. 12060-12068, ACS Publications, 2017
external page DOI: 10.1021/jacs.7b06773